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Myeloid-Derived Suppressor Cells and Cancer 2016 book

Myeloid-Derived Suppressor Cells and Cancer 2016 book

Myeloid-Derived Suppressor Cells and Cancer 2016 by Grazyna Kochan
Myeloid-Derived Suppressor Cells and Cancer 2016
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Author: Grazyna Kochan
Number of Pages: 111 pages
Published Date: 09 May 2016
Publisher: Springer International Publishing AG
Publication Country: Cham, Switzerland
Language: English
Format: PDF
ISBN: 9783319268194
File Name: myeloid-derived.suppressor.cells.and.cancer.2016.pdf
Download Link: myeloid-derived suppressor cells and cancer 2016
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The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

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